Full disclosure: I hate iTunes. I've used it in the past, both for music and for podcasts, and I just don't like using the program. Thankfully, they're not the only aggregator out there anymore.
I subscribe to lots of NPR shows that I don't get the chance to listen to during the regular course of life. Car Talk, Wait, Wait..., Science Friday, and a series called RadioLab. I used to subscribe to more, but the files would just pile up as I never had time to listen to them all. The NPR website makes it easy to subscribe to the podcasts without using iTunes.
I've occasionally subscribed to other podcasts using various other techniques, but they've fallen by the wayside as I've had other demands on my time this year.